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Figure 2 Glutathione Metabolic Pathway The activity of lipid repair enzyme called GPX4 which exerts an antioxidative effect on ferroptotic process depends on the biosynthesis of glutathione (GSH) ( Lipid Peroxidation Pathway Researchers have discovered that ferroptosis is preferentially accompanies by lipid peroxidation including polyphosphorylated phosphatidylethanolamine (PE) containing polyunsaturated fatty acids (PUFAs) ( NADPH-FSP1-CoQ10 Pathway It has been demonstrated by Doll and colleagues that overexpression of apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also named as FSP1) ( 10 antioxidant system ( Iron Metabolism Pathway Both process and development of ferroptosis relies on overload iron that ascribe to peroxides and divalent ferrous salts produced by fenton reaction

R., Dupouy-Camet, J., Khazan, H., & Bruschi, F

The extrinsic pathway involves the activation of a protease cascade intitated by the activation of caspase 8 through the action of death receptors and their ligands, for example, FasL, and tumor necrosis factor- (181)

All statistics were done using non-parametric two-sided Wilcoxon rank sum test

While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored