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Autophagy prevents tumor formation during the initial stages, however once tumors are established, autophagy may paradoxically promote tumor growth by protecting them from metabolic stress [1]

However, 1 O 2 has a brief lifespan and limited diffusion range, restricting its damage within the cell diameter

Cortes JE, Kantarjian HM, Kadia TM, Borthakur G , Konopleva M, Garcia-Manero G, Daver NG, Pemmaraju N, Jabbour E, Estrov Z, Ramachandran A, Paradela J, Pond B, Ravandi F, Vusirikala M, Patel PA, Levis MJ, Perl AE, Andreeff M, Collins R

Nature 483 , 218221 (2012)