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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Yajnik CS, Deshpande SS, Panchanadikar AV, Naik SS, Deshpande JA, Coyaji KJ, Fall C, Refsum H

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Peptide research brief BPC-157: mechanism, in vitro studies, and gaps in human evidence Common name BPC-157 Classification Synthetic peptide fragment (gastric pentadecapeptide) Sequence GEPPPGKPADDAGLV Molecular formula C62H98N16O22 Molecular weight 1419.55 Da CAS 137525-51-0 BPC-157: mechanism, in vitro studies, and gaps in human evidence The proposed bpc-157 mechanism of action centers on a pro-angiogenic signaling cascade reported across rodent and cell-culture experiments, with VEGFR2 receptor activation and downstream endothelial nitric oxide synthase (eNOS) phosphorylation as the most frequently cited nodes (Hsieh et al., 2017

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However, an important limitation remains: Current evidence is primarily preclinical, with limited published human clinical data

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