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The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients
It is essential to mention that the cardiac toxicity potential of mitoxantrone has decreased compared to doxorubicin (Durr et al., 1983)
Furthermore, it is pertinent that future in vivo and clinical investigations consider sex effects
However, in cases of generalized rapid progression, oral corticosteroids are required to decrease disease progression
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