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In contrast, endogenous 4-1BB signaling upregulates PGC-1 through stimulation of the p38-MAPK pathway, resulting in mitochondrial fusion and biogenesis and substantially increasing T cell respiratory capacity
10.1038/nmeth.1923 29 LewisT.CookJ
Statistics on the mean and standard error of the mean were performed using a two-way ANOVA with a Tukeys post hoc test
We could prove that this effect is linked to the presence of the Se core, since CS-NCs showed low levels of apoptosis in both cancerous and normal cells
Several other potential therapies are being studied
