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But under oxidative stress conditions induced by reactive species, toxins or ARE inducers, the association between Nrf2 and Keap1 is disrupted and Nrf2 translocates to the nucleus of the cell, where it binds to small Maf proteins that increase the transcription of genes driven by ARE [67]

Evidences from studies have indicated that mTORC1 inhibits autophagy by activating the ULK complex

Erastin exploits the defective mitophagy-driven ROS accumulation to circumvent the ferroptosis resistance characteristic of EESCs, thereby enhancing its therapeutic efficacy

The main effects of fatty acid (FA) treatment are shown

doi: 10.3945/jn.112.173229 82 NalumansiP