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Gonzalez, 2007

Inflammatory Macs, regarded as chemokine high macrophages [104] or nonfoamy macrophages [7], not only constitute plaque macrophage populations but are also considered to be the main drivers of inflammation [105,106,107] in the lesions because of the many inflammatory pathways involved in this subset of cells with high expression of inflammatory genes, including Ccl2-5 , Cxcl1 , Cxcl2 , Il1 , Nlrp3 , Nfkbia , Tnf and Ear1 [101], similar to the gene profile of M1-like macrophages

Our study demonstrates that supplementing with -ketoglutarate, the -keto acid of glutamine, can serve as an alternative metabolite to mitigate systemic glutamine dependence, glucose intolerance and simultaneously address concerns related to ammonia neurotoxicity

Could I be drinking too much

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