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Further longitudinal analyses in initially non-depressed subjects are needed to properly disentangle these two mutually non-exclusive scenarios

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In addition, several type IIa muscle fiberspecific genes (such as MyHC I and MyHC IIa ) may be coregulated by both signaling pathways, but the AMPK/SIRT1/PGC1- pathway focuses more on indirectly supporting the formation of type IIa muscle fibers through mitochondrial synthesis and metabolic regulation, whereas the PKA-CREB pathway mainly regulates the expression of type IIa muscle fiberspecific genes directly through ERR

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