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PMID: 17156758 James PA et al (2014): Evidence-Based Guideline for the Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
The data are consistent with the hypothesis that the cysteine S -conjugate of cisplatin is a -lyase substrate of mitAspAT and that the released PtSH fragment reacts with proteins in kidney mitochondria especially KGDHC
doi: 10.1530/JOE-15-0201 [DOI] [PubMed] [Google Scholar] 359
TME is a complex ecosystem composed of tumor cells, extracellular matrix (ECM), innate and adaptive immune cells, inflammatory cells, tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), tumor-associated neutrophils, myeloid-derived suppressor cells (MDSCs), endothelial cells, microvascular networks, as well as various cytokines and chemokines (Wu et al., 2022)
The control mice displayed a robust CAT activity of 83.33 4.93 U/mg
