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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

This approach mirrors dosing strategies used for other peptides with 1216 hour half-lives, though published 5-amino-1mq pharmacokinetic data in humans remains limited

Supplementation may involve various forms of cobalamin: adenosylcobalamin, cyanocobalamin, methylcobalamin, or hydroxocobalamin

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It is not approved by the FDA for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease