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Br J Pharmacol 2009;158:1153-64

Curcumin, while poorly absorbed in its native form, undergoes significant metabolic transformation in the liver, resulting in metabolites that are excreted in the urine and contribute to its anti-inflammatory effects

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Biosynthetic pathway of free heme The biosynthetic pathway of heme is divided into three modules in microorganisms, including 5-aminolevulinic acid (ALA), uroporphyrinogen (urogen) III, and heme synthetic modules (Fig