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In some scenarios, these approaches may violate Occams razor (that the simplest effective intervention is preferable), especially if they fail to outperform less complex, lower-cost alternatives, which so far do not demonstrate durable or disease-modifying benefits

HOMA-IR: homeostatic model assessment insulin resistance

Acknowledgments We would like to thank the Addis Ababa University, College of Natural and Computational Sciences, left for Food Science and Nutrition

The causes of LOAD are still unknown, but several factors have been shown to modify the risk of developing LOAD, such as environmental, lifestyle, ethnic, socioeconomic, and genetic factors

This process effectively reduces the plasma iron concentration by blocking the two primary routes of iron into the circulation-intestinal iron absorption and iron-recycling by macrophages-while intracellular labile Fe is retained (Nemeth et al., 2004[323])