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Reports have suggested that these drugs may inhibit various -glutamyl cycle enzymes, including 5-oxoprolinase

A significant decrease in Cx43 expression causes sudden arrhythmic death [89]

: Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster

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In addition, reduced glutathione deficiency in regulatory T cells (Treg) leads to abnormal serine metabolism and down-regulates transcription factor forkhead box P3 (Foxp3), which ultimately attenuates the immunosuppressive function of Treg (56)