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However, it is well known that melanoma prognosis depends mainly on Breslow thickness rather than the histologic subtype, and until now we do not have a reliable marker to predict which lesion will evolve to invasive melanoma [1315]

Studied in melanocortin receptor, pigmentation, melanin signalling, photoprotection and intranasal delivery research models

There are two different grading classifications: One depends on the World Health Organisation (WHO) classification for soft-tissue tumors with a grading scale from I-III, the other one on the WHO classification for tumors of the nervous system with a grading scale IIIandIV[5, 6]

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