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Post-hoc subgroup findings are hypothesis-generating, not confirmatory they do not change the fact that the prospectively-defined primary endpoint failed

Both do, within their pharmacokinetic constraints
Viral-mediated adipocyte infection (cellular entry, invasion, and propagation) processes could inflict severe adipose tissue dysfunction and insulin resistance 754,755
Debele TA, Wu PC, Wei YF, Chuang JY, Chang KY, Tsai JH, et al
Understanding and reversing mechanisms contributing to ACD are important because increased age is identified as the single most important risk factor for dementia
