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L-Carnitine plays a crucial role in energy production by transporting fatty acids into the mitochondria, where they can be burned for energy

doi: 10.1016/j.freeradbiomed.2020.12.017 189 MagroneTRussoMAJirilloE

Phase II results Phase II participant characteristics Baseline characteristics for the 16 participants from Phase I who completed Phase II are shown in Table 2

In NAFLD patients, Godex supplementation significantly reduced ALT and AST, increased mtDNA copy number, and decreased oxidative stress marker 8-oxo-7, 8-dihydro2'-deoxyguanosine (8-oxo-dG) ( L-carnitine also ameliorates oxidative stress by reducing ROS production ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) ( Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis

No head-to-head comparison has been conducted