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Muoio DM (2014) Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock

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Homozygous null deletion of the Kat6a gene in mice causes foetal to perinatal death (depending on the genetic background), characterised by cleft palate, shortened jaws, cardiac septum defects, and interrupted aortic arch, as well as an anterior homeotic transformation of 19 body segments affecting the vertebral column and the nervous system (Voss et al, 2009, 2012

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ALCAR was either administered orally (4 g/day for 90 days) in four trials or intravenously (4 g/day for three days) in one trial