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On the other hand, the 3D-sphere formation phenotype was affected by the sole inactivation of GLCM (Fig

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However, this was not associated with a significant improvement in motor behavior[42], suggesting that targeting muscle alone without restoring motor neuron function is not sufficient to reverse a severe form of SMA

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79 Mast cells may stimulate microenvironmental cNF changes by inducing the formation of a collagenous matrix by transforming growth factor beta (TGF-)-mediated stimulation of cNF fibroblasts, and by secretion of other molecules such as platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF) and histamine

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Hence, there is an urgent need to explore new targets for its treatment

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