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This was recently reported in three individuals who developed thiamin deficiency after gastric bypass surgery

Many people dont realize just how much B12 influences how they feel until they replenish it

For recovery enhancement, performance optimisation, or longevity goals in healthy people, until a randomised, placebo-controlled trial in a defined population with an objective primary endpoint and pharmacovigilance over a clinically meaningful duration produces data we do not currently have, we just don't have good evidence of benefit, let alone safety

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