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GSH also detoxifies electrophilic xenobiotics compounds (chemical carcinogens, environmental pollutants, drugs, etc.) and their metabolites to GSH adduct (GS-X) in the direct catalysis of glutathione-S-transferase (GST, primary approach) [32]

A key challenge arises from the cysteine residue, which is prone to heterogeneous post-translational modifications of the thiol group that result in multiple unknown isoforms, effectively diluting an already low-density target 17

The PT is the most sensitive renal segment to injury partly due to its high metabolic rate, oxygen dependency, and higher exposure to toxins

Valeriana officinalis counteracts rotenone effects on spreading depression in the rat brain in vivo and protects against rotenone cytotoxicity toward rat glioma C6 cells in vitro
