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Aug 15 2012;8(4):357-65

Thus, while the lactate-TCA cycle-oxidative phosphorylation (OXPHOS) axis is well supported, whether lactate enters mitochondria directly or is first converted to pyruvate in the cytosol remains uncertain, and the preferred route may vary across different tissue types or metabolic conditions [2]

Collectively, these findings suggested that LPS exerted a bidirectional influence on immune responses in asthma, with effects depending on exposure context

Baran N, Han L, Stuani L, Cavazos A, Cooper L, Ramage CL, Kuruvilla VM, Zhang Q, Sabtier M, Boet E, Gay JP, Feng N, Battula VL, Chu-Van E, Castelli F, Carroll M, Konoplev SN, Thakral B, Daver N, Marszalek JR, Ge Y, Andreeff M , J-E S, and Konopleva MY