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Other patients take vitamin B12 as a nasal spray

Here is a revised and more accurate explanation of the reasons a UK GP surgery might refuse to give a B12 injection a day earlier than scheduled, incorporating the points youve raised and providing a more scientifically grounded perspective: 1

Ca 2+ homeostasis imbalance Upon the release of the excitatory neurotransmitter glutamate from the presynaptic terminal, it initiates the activation of postsynaptic receptors, thereby inducing alterations in the electrical potential across the postsynaptic membrane

An upregulation of the Nox4 expression with downregulation of the catalase expression and/or activity in diabetes increases the hydrogen peroxide concentration which promotes retinal neovascularization through the VEGF signaling pathway [82]

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