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In fact, sample size estimates have indicated the need for a reasonable number of donors (n = 13299) to detect 2-fold changes in a panel of inflammatory readouts (e.g., IL-6 and IL-8 transcripts) to account for interindividual variability in studies using an in vitro primary cell-based model exposed to ozone ( in vitro assays ( Despite some of the limitations discussed above, the NAM toolbox for respiratory safety used in this work appeared to separate the low- and high-risk benchmark exposure scenarios for 12 out of the 14 scenarios evaluated when using the BER, suggesting that our strategy of selecting NAMs informed by AOPs associated with pulmonary toxicity, can provide relevant biological coverage

Based on the characteristics of hormesis, moderate stimulation can induce various stress responses and enhance organism resistance, thereby exerting positive effects on the body

The lactate-driven acidification directed monocyte differentiation (in the presence of GM-CSF and IL-4) toward immunosuppressive tumor-associated DCs with impaired CD8 + T cell priming capacity

Studies have demonstrated that hippocampal neurons are highly sensitive to the effects of systemic cytokines, which can alter synaptic plasticity, reduce long-term potentiation (LTP), and impair neurogenesis (Venkateshappa et al., 2012

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