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JAK inhibitors represent another class of targeted therapy, but like anti-TNF agents, they come with significant immunosuppressive effects

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Another modification of the method is Raman optical activity (ROA) that detects chiral molecules by measuring a small difference in their vibrational Raman scattering intensity when illuminated with right- and left-circularly polarized light (incident circular polarization, ICP) (Zhu et al., 2005)