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6.4 Acupuncture effects in comparison with pharmacological inhibitors and dietary interventions for ferroptosis regulation Pharmacological agents like liproxstatin-1 are specific inhibitors of lipid peroxidation, functioning by inhibiting GPX4 activity and preventing the accumulation of lipid hydroperoxides, which are key mediators of ferroptotic cell death (Fan et al., 2020)

By acting as an antioxidant, glutathione helps reduce oxidative damage at the skin surface

Key Ingredients: Glutathione Strong antioxidant that reduces melanin production

Exposure to microplastics leads to decreased mitochondrial function, induces oxidative stress and ferroptosis, and causes abnormal expression of genes related to mitochondrial function, such as increased expression of mitochondrial transcription factor A (TFAM), thereby associating them with neurodegenerative diseases including Alzheimers disease and Parkinsons disease (50)

Kelch-like Ech-associated Protein-1 (KEAP1) keeps Nrf2 tethered in the cytoplasm, where it is degraded in an unstressed state by the ubiquitinproteasome system