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Approximately 98% of IGF-1 exists as a bound form to one of the IGFBPs, with IGFBP3 accounting for 80% of all the binding
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55 However, the authors did not interpret this as evidence for therapeutic effects of NAC but of the fluctuating course of the biochemical parameters in NASH

This is because of their exceptional physicochemical properties, including a high surface area, straightforward synthesis and modification, and the ability to activate brain immune responses
