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10.3390/antiox10010075 39

, Kodawska K., and Malec P
PLGA nanoparticle-based formulations to cross the bloodbrain barrier for drug delivery: from R&D to cGMP

However, it was not recognized at the time that evidence for the protein binding hypothesis was obtained in animals on a normal diet whereas the LPO hypothesis was derived from animals fed a vitamin E-deficient diet high in polyunsaturated fatty acids (PUFAs), i.e., in animals highly susceptibility to LPO [61]

Konstantopoulos N, Molero JC, McGee SL, Spolding B, Connor T, de Vries M, et al
