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Description
The excess nitric oxide reacts with superoxide radicals to form peroxynitrite, a highly destructive oxidant that damages cellular membranes, proteins, and DNA

This direct delivery bypasses the skin barrier, which can limit the absorption of topically applied ingredients, ensuring more consistent and potent therapeutic levels

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Funding This study received no external funding

Therefore, DA would presumably inhibit SS release at least at two levels (the hypothalamus proper and the median eminence)
