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Estrogens exert antidepressant activity via multiple mechanisms: the regulation of 5-HT synthesis, metabolism and function, and neurotrophic activity to promote neuroplasticity and neurogenesis [95]
Marxen, S
However, despite strong preclinical evidence, turning micronutrient therapy into standard clinical guidelines is complicated
[29] [30] [31] [32] Insomnia may be a factor in causing sleep deprivation
Neurology 69 , 21972204 (2007)
