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IGF-1/IGF-1R knockout mice showed decreased brain size, loss of myelination, and cognitive decline, whereas overexpression of IGF-1 resulted in increased brain size and myelination [32]

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Protein disulfides serve as inter- and intra-subunit crosslinks in secondary and tertiary protein structures, and, as such, play a critical role in maintaining the structure of many proteins, including mucus proteins [194]

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