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If CXXC5 is still suppressing Dishevelled, the signal that tells the destruction complex to stand down never arrives properly

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Downregulation of SLC7A11, a specific amino acid transporter protein, can indirectly inhibit GPX4 activity by inhibiting the cysteine metabolic pathway, leading to decreased intracellular cystine levels and depletion of glutathione (GSH) biosynthesis, which, in turn, leads to the accumulation of lipid peroxides and ultimately induces ferroptosis in cells [13]

& Raul, F

doi: 10.3389/fendo.2022.963451
