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In addition, the benchmarking approach provides an alternative to the traditional validation of NAMS against apical effects in rodent studies but rather tries to evaluate the NAMs in the context of making protective safety decisions ( in vitro culture methodologies (van der Zalm et al., 2022)

doi: 10.1136/thoraxjnl-2018-212136 105 PonganisP

By addressing current limitations in mechanistic understanding, manufacturing scalability, and clinical trial design, MSC-based interventions may transition from investigational agents to first-line therapies for a broad spectrum of disorders spanning multiple organ systems and disease categories with heterogeneous etiologies

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