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doi: 10.1007/s40121-020-00288-4 Marroush TS, Sharma AV, Botros B, Szpunar S, Rosman HS, Mehta RH

Affected individuals have reported complaints of fatigue, exercise intolerance, and muscle aches

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Regulation of Acetyl-CoA/CoA Ratio Under physiological conditions, carnitine can buffer excess acetyl-CoA in the mitochondria via the formation of acetyl-carnitine (33), which requires the presence of carnitine acyltransferase and carnitine acylcarnitine translocase