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Abbreviations ASD: Autism spectrum disorder C1: One-carbon CFD: Cerebral folate deficiency CNS: Central nervous system DA: Dopaminergic FOLH1: Folate hydrolase 1 FR: Folate receptor FR: Folate receptor FR: Folate receptor FR: Folate receptor FRAAs: Folate receptor autoantibodies bFRAAs: Blocking autoantibodies to folate receptor GPI: Glycosylphosphatidylinositol MTHFR: Methylenetetrahydrofolate reductase 5-MTHF: 5-Methyltetrahydrofolate NMDA: N-methyl-D-aspartate Pax3: Paired box 3 PCFT: Proton-coupled folate transporter RFC: Reduced folate carrier SCF: Cerebrospinal fluid TRP/TRPM: Transient receptor potential superfamily, melastatin-related subfamily References Saitsu H (2017) Folate receptors and neural tube closure

Systemic Detoxification: Uses powerful antioxidants to neutralize free radicals and reduce systemic inflammation, which is often the precursor to chronic illness

Although the exact mechanism linking low serotonin levels to migraine pathology has not yet been fully described (Hamel 2007), researchers have hypothesized that serotonin may interfere with pain processing in the brain

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It exists as two enantiomers: (R)-(+)-lipoic acid (R-ALA) and (S)-()-lipoic acid (S-ALA), and as a racemic mixture