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Inefficiency of the phagocytosis process leads to the formation of residual lipid-protein granules that cannot be degraded, known as lipofuscin, and generation of ROS occurs from the constant exposure of lipofuscin to light and oxygen tension 1
(PMC) A fourth mechanism is circadian and neuroendocrine regulation, especially through pineal activity and melatonin rhythm normalization
Jeong EA, Jeon BT, Shin HJ, Kim N, Lee DH, Kim HJ, et al
