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Such targets include strategies for microbiome modulationusing agents like berberine and ginkgolide Bas well as emerging miRNA-based therapies aimed at restoring homeostatic gene expression (e.g., through PER2 regulation)

Acknowledgements Not applicable

Germ free animals used were obtained from the University of North Carolina Gnotobiotic Facility, which is supported by P30-DK034987-25-28 and P40-RR018603-06-08

PQQs antioxidant properties may help reduce oxidative stress

Allicin reduced TMAO levels in mice fed with high choline
