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Injection of high-dose (50 mg/kg) or low-dose curcumin (10 mg/kg) increased bone density and promoted trabecular bone formation
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This is a key distinction in the GHK-Cu vs GHK-Cu Cosmetic discussion

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Moreover, a recent meta-analysis-based retrospective study indicated an elevation in blood homocysteine level as a risk factor for patients with CVD and End-stage Renal Disease ESRD, not treated with any folic acid supplementation [78, 81]