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Similarly, many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular reabsorption

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The build-up of fatty acyl CoA derivatives is known to inhibit insulin signaling and glucose oxidation in muscle [1]

Other studies have demonstrated a dose-dependent effect of acetyl-l-carnitine in counteracting oxidative stress caused by arsenic and improved mitochondrial function in a rat hippocampus model and reduced the levels of free radicals induced by cuprizone in murine corpus callosum [21, 22]
