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They found that iron, ACSL4, and MDA levels increased with increasing reperfusion time, with concomitant decreases in GPX4 levels, and deferoxamine treatment significantly ameliorated myocardial injury [88]

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It acts as the ultimate electron donor for the glutaredoxin system, which activates ribonucleotide reductase (RNR) , the rate-limiting enzyme responsible for converting ribonucleotides into the deoxyribonucleotides (dNTPs) needed for DNA replication