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Description
This study provides the first comprehensive insight into the human-relevant metabolic profile of GBT1118, offering valuable guidance for doping control, which also serves as an effective tool for human metabolic research of other HbS-PIs

Slow titration schedules, typically adding one dose increment every four weeks, appear to reduce dropout rates due to gastrointestinal side effects
5 , 6 It appears that acute treatment strategies (shortly after the induction of disc injury) as used and studied in most preclinical IVD degeneration models do not reflect the real life clinical chronic pain situation

Nervenarzt (2006) 77: 1228
EBioMedicine 40, 432445
