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ECM plays an essential role in modulating lung structure and function [291, 292], and its alteration can result in lung disease [291, 293, 294]

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This chronic inflammation can lead to insulin resistance, increased fat storage, and difficulty losing weight

In the same cohort, MACE risk was found to be about 30% higher in individuals in the highest versus lowest quartile of choline or betaine plasma concentrations (115)

doi: 10.3390/ph17121665 40 FuZ.HanF.HuangK.ZhangJ.QinJ