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Issues such as biocompatibility and safety concerns, the complexity of manufacturing and quality control, optimization of drug delivery efficiency, understanding of nano-bio interface interactions, assessment of long-term side effects and cumulative toxicity, cost issues, the complexity of clinical trial design, and drug resistance are all challenges that must be faced in the clinical translation of nanomedicine

Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, et al

& Chopp, M

H.ZeltJ

GSH supplements would seem to be the most efficient way to increase cellular levels of GSH because if significant amounts of GSH are absorbed intact and are biologically active and also if the digestion process breaks down additional amounts of the supplemental GSH into its precursorswhich would then be also absorbed and available for recombination into GSHthe inter- and intracellular GSH transport mechanisms would be shifted in favor of increased cellular GSH