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They are a prognostic sign in several atherothrombotic diseases, including acute coronary syndrome, thrombosis, and stroke

10.1038/s41577-019-0198-4 141 TrammellS

1 2 "Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay"

Toll-like receptors and complement substances initiate and perpetuate these responses and lead to monocyte and glomerular cell activation

Research has shown that 40 to 90% of RLS cases have at least one first-degree relative with RLS
