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In these methods, enzyme variants are encoded by DNA templates that can be generated by a variety of means, including from commercial gene synthesis, error-prone PCR, and saturation mutagenesis

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Studies show that ICA could effectively reduce the male reproductive dysfunction and spermatogenesis defects induced by diabetes mellitus (DM), promote the release of testosterone, inhibit the expression of testicular type IV collagenase and transforming growth factor--1, and thus protect the testicular damage caused by diabetes mellitus

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(38) conducted a parallel clinical trial assessing the effects of 2 g/day of extended release niacin, 4 g/day of omega-3 fatty acids, a combination of the two, or a respective dual placebo for 16 weeks on plasma lipids and lipoproteins in 56 adults with metabolic syndrome