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For example, general control nonderepressible 2 (GCN2) is activated by amino acid starvation, whereas protein kinase-like endoplasmic reticulum kinase (PERK) is activated by endoplasmic reticulum (ER) stress 15

gene therapy vectors will be as the expression vectors described above in the sense that they comprise the nucleotide sequence encoding agent to be expressed, whereby the nucleotide sequence is operably linked to the appropriate regulatory sequences as indicated above