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While there are a number of hypotheses underlying this disease, an increase in glutamatergic neurotransmission has been proposed as a key event in the disease onset and recently, this has been described, at least in part, to a defect in the function of the GLT-1 glutamate transporter which is localized on astrocytes [65]

In the CY 2021 HH PPS final rule (85 FR 70298), we stated that if appropriate, we would propose any updates from OMB Bulletin No

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[123] Alternative feeding methods or antiemetic medications with better-established lactation safety profiles may be appropriate in some circumstances