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Recombinant adeno-associated virus carrying the ABCA1 gene can target delivery to vascular endothelial cells or macrophages to enhance cholesterol efflux and improve plaque size [164]

The most well-established among them appears to be nuclear factor erythroid 2-related factor 2 (Nrf2), which is likely activated by redox status changes of the kelch-like ECH associated protein 1 (Keap1) induced by NAPQI

Furthermore, the apolipoprotein E4 (ApoE4) gene mutation is complex in AD neuropathology due to the buildup of A and limits its clearance (Alsubaie et al., 2022

But theres a difference between association and causation

Following centrifugation at 15,000 g for 5 min, the absorbance of the clear supernatant was measured at 400 nm using a Scanning Multi-Well Spectrophotometer (Sunrise