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The rationale is an extrapolation from two separate preclinical stories, stitched together by marketing and community folklore
Aceast interaciune este asociat cu modularea expresiei genice, fr modificarea direct a codului genetic
[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility
Slade, R
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