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doi: 10.1586/eem.09.64 [DOI] [PMC free article] [PubMed] [Google Scholar] 182

Novel nanoparticle-based delivery systems for ferroptosis modulators, including their loaded drugs, targeting strategies, and advantages are outlined in Table 3
We therefore propose a simple, testable framework: CSCs from embryonal/embryonic-like tumors may depend on ferritin chiefly to buffer iron and preserve stemness under fluctuating microenvironments, whereas CSCs from differentiated epithelial tumors may exploit iron in specialized metabolic or redox processes, In this context, ferritin loss can trigger stress-adaptive programs (proliferation, migration, EMT) that paradoxically increase aggressiveness [123,124,125]

Kam et al

An in vivo study showed that BC rats, after pomegranate juice administration, showed reduced IL-6 , TNF- , and HIF-1 expression compared to BC animals