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A high B12 in someone who isn't taking B12 supplements is the version that most warrants a deeper look

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Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations, we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD+ salvage cycle

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This is because B12 is only found naturally in animal foods